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Breakage
Tablet Core
- Tablets are too soft or too brittle Investigate core improvement
- Tablets cap/laminate Change tablet compression profile
- Poor tablet shape for coating Change tablet shape
Process/Equipment
- Pan speed too high Decrease pan speed
- Inappropriate baffle design for tablet shape Change baffle design
- Spray rate too low Increase spray rate
- Suspension solids concentration too low Increase suspension solids concentration (if possible)